Endocrine Abstracts

Introduction: Adrenocortical Carcinoma (ACC) is a rare endocrine neoplasm with poor prognosis, and an estimated incidence of approximately 2.5/1,000,000 patients. The functional state of these tumors varies from non-secretory (20%) to non-secretory. The latter category is subdivided into glucocorticoid-producing (45%) or glucocorticoid-androgen producing (45%) or androgen-producing only (10%). We report a case of a 35-year-old lady who initially presented with symptoms of Cush...

Introduction: Cushing’s syndrome is a rare endocrine disorder characterized by excess cortisol secretion. It can be caused by various etiologies, including ACTH-dependent and ACTH-independent forms. We report a case of a 78-year-old male who presented with severe hypertension, refractory hypokalemia, and severe hypercortisolaemia, diagnosed with ACTH-dependent Cushing’s syndrome with bilateral adrenal hyperplasia.Case Presentation: A 78-year-ol...

Objective: To evaluate the association between genetic background and the presence of oligo- or amenorrhea in a sample of adolescent girls diagnosed with anorexia nervosa compared with controls.Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calculated body mass index (BMI) z-scores adjusted for age, as wel...

Introduction: The aim of this study was to evaluate the association between a personal history of lactation and indices of subclinical atherosclerosis and arterial stiffness in postmenopausal women.Patients and methods: This cross-sectional study included 283 postmenopausal women. Sonographically assessed indices of vascular function [pulse wave velocity (PWV)] and vascular structure [intima-media thickness (IMT), atherosclerotic plaque presence] were te...

Introduction: A growing body of evidence is supporting a beneficial impact of breastfeeding on maternal metabolism and overall cardiovascular risk. The aim of this study was to evaluate the association between prolactin levels and metabolic parameters as well as indices of subclinical atherosclerosis, in a sample of premenopausal women with normal levels of prolactin.Patients and Methods: This cross-sectional study included a total of 64 non-lactating pr...

Introduction: The aim of this study was to investigate the incidence of hypertension and to identify potential risk factors in healthy, non-diabetic recently postmenopausal Greek women with normal renal function.Patients and methods: In this retrospective cohort study, we evaluated 141 recently postmenopausal women at baseline and annually thereafter (follow-up time: 1 to 8 years). Blood samples were obtained and ultrasound evaluations were performed at ...

Introduction: Ovarian senescence and fluctuating levels of sex hormones is associated with metabolic derangement and central obesity. The aim of this study was to explore the association between serum levels of sex hormones and metabolic health in non-obese postmenopausal women.Patients and methods: This cross-sectional study included a total of 457 non-obese postmenopausal (BMI <30 kg/m2) women, retrieved from the Menopause Clinic of Aret...

Introduction: Single nucleotide polymorphic variants of the methylenetetrahydrofolate reductase (MTHFR) gene have been related with a tendency to gain weight according to recent studies. The aetiology of atypical anorexia nervosa remains under investigation and might be associated with the genetic background. The aim of this study was to evaluate the association between the presence of A1298C or C677T polymorphisms of the MTHFR gene and weight status in a sample of adolescent ...

Introduction: Prenatal and perinatal food manipulation might be related with bone quality in offspring of Wistar rats. This study aimed to assess the impact of different dietary patterns provided before delivery to the mothers on the skeletal characteristics of newborn rats and the levels of insulin.Materials and methods: We randomized 67 timed-pregnant rats into control diet (CD), high-fat (FD) and food-restricted (FR) on the 12th day of gestation. The ...

Introduction: Recent evidence recognized the value of Retinol-Binding Protein (RBP4), as potential biomarker of cardiovascular and cerebrovascular pathology. The possible association between RBP4 and functional vascular disease remains unexplored, while recent data in postmenopausal populations suggested lack of association between RBP4 and subclinical atherosclerosis. We evaluated the possible link between RBP4 and menopause-specific cardiovascular risk factors, in a sample o...